HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 18788311, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Sodium borohydride | HCID 4311764 | — |
| Reactant | HCID 15463648 | HCID 15463648 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 18788311 | HCID 18788311 | 150.8% |
Reaction Steps
To 40 mg (0.11 mmol) of 2-chloro-6,8-dihydroxy-9-oxo-7-propyl-9H-pyrrolo[2,1-b][1,3]benzoxazine-1-carboxaldehyde made by the process of Example 9 in 4 mL of EtOH and 4 mL THF was added 20 mg of sodium borohydride. After 15 min the mixture was diluted with H2O and ethyl acetate and 1 mL of 1 N HCl with vigorous bubbling. The mixture was extracted with ethyl acetate and the organic layer dried (Na2SO4) and concentrated to give 48 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06057315 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-c5f9bbdb27984103b1f622844594cecb |
| Source note | uspto-grants-2000_05 |