2-[5-(4'-{2-[1-(5,5,5-Trifluoro-2-methoxycarbonylamino-pentanoyl)-pyrrolidin-2-yl]-3H-imidazol-4-yl]-biphenyl-4-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carboxylic acid tert-butyl ester → 2-{5-[4'-(2-{1-[2-Methoxycarbonylamino-4-(2,2,2-trifluoro-ethoxy)-butyryl]-pyrrolidin-2-yl}-3H-imidazol-4-yl)-biphenyl-4-yl]-1H-imidazol-2-yl}-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][cH:20][c:21](-[c:24]4[cH:25][cH:26][c:27](-[c:30]5[nH:31][c:32]([CH:35]6[N:36]([C:40]([CH:41]([CH2:42][CH2:43][C:44]([F:45])([F:46])[F:47])[NH:48][C:49](=[O:50])[O:51][CH3:52])=[O:53])[CH2:37][CH2:38][CH2:39]6)[n:33][cH:34]5)[cH:28][cH:29]4)[cH:22][cH:23]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1.[CH3:54][O:55][C:56](=[O:57])[CH:58]([NH:59][C:66]([O:67][CH3:68])=[O:69])[CH2:70][CH2:71][O:60][CH2:61][C:62]([F:63])([F:64])[F:65]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([c:13]2[nH:14][c:15](-[c:18]3[cH:19][cH:20][c:21](-[c:24]4[cH:25][cH:26][c:27](-[c:30]5[nH:31][c:32]([CH:35]6[N:36]([C:40]([CH:41]([CH2:42][CH2:43][O:60][CH2:61][C:62]([F:63])([F:64])[F:65])[NH:48][C:49](=[O:50])[O:51][CH3:52])=[O:53])[CH2:37][CH2:38][CH2:39]6)[n:33][cH:34]5)[cH:28][cH:29]4)[cH:22][cH:23]3)[cH:16][n:17]2)[CH2:10][CH2:11][CH2:12]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-047105ffd453482baf4b296ede9b0439
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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