Pyridine → 3-(2,4-Dimethylphenyl)1,2,4-oxadiazolin-5-one

HRID 1106473Notes

Reaction equation

HRID 1106473 reaction equation
[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4](=[N:6][OH:7])[NH2:5].N1C=CC=CC=1.Cl[C:20](OCC)=[O:21]>C1(C)C=CC=CC=1>[CH3:1][C:2]1[CH:11]=[C:10]([CH3:12])[CH:9]=[CH:8][C:3]=1[C:4]1[NH:5][C:20](=[O:21])[O:7][N:6]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 10928Ethyl chloroformateHCID 4328521N'-hydroxy-2,4-dimethylbenzenecarboximidamide

Product 1

HCID 1361385563-(2,4-Dimethylphenyl)1,2,4-oxadiazolin-5-one

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Under an inert atmosphere, 10.5 g of 2,4-dimethyl benzamidoxime are dissolved in 40 ml of anhydrous toluene; 6.5 ml of pyridine and 7.6 g of ethyl chloroformate are added.

Sources & evidence

ORD record
ord-5ae52936789a431eb97e57d85ffe9a81
Source dataset
uspto-grants-2000_05
Patent number
US06057318

Reaction notes

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