Acetic Acid → HCID 18788592, compound

Participants

Reaction Steps

To 3-cyclohexylethynyl-6,7-dimethoxyquinoline (215 mg; 0.73 mmol) in 10 mL CH3OH and 20 mL glacial acetic acid is added 22 mg 10% Pd/C. H2 is bubbled through the reaction mixture and then filtered, evaporated to dryness and diluted with distilled water. This is then neutralized with Na2CO3, extracted with EtOAc, washed with brine, dried (MgSO4), evaporated to dryness and chromatographed with 8:2/hexane:EtOAc to obtain 3-cyclohexyl-ethyl-6,7-dimethoxyquinoline.

Provenance & Evidence