反应详情

To a 25 mL flask with 10 ml of abs. EtOH is added 0.137 g of 4-chloro-6,7-dimethoxyquinazoline and 0.087 g of 1-aminonaphthalene. The solution is heated to reflux whereupon the insoluble materials dissolve. After 5 minutes at reflux a precipitate forms. The solution is allowed to stir an additional 10 minutes before cooling and isolation of the product as the hydrochloride salt by simple filtration. High-vacuum drying of the solid provided analytically pure (6,7-dimethoxy-quinazolin-4-yl)-alpha-naphthalenylamine (0.142 g, white powder, m.p. 271-273° C.

1. temperatureThe solution is heated
2. temperatureto reflux whereupon the insoluble materials
3. dissolutiondissolve
4. temperatureAfter 5 minutes at reflux a precipitate forms
5. temperaturebefore cooling
6. filtrationisolation of the product as the hydrochloride salt by simple filtration
7. customHigh-vacuum drying of the solid