Water → HCID 15453627, compound

Participants

Reaction Steps

Ethyl 3-ethoxycarbonylmethyl-3-methoxycarbonyl-4-oxo-1-piperidineacetate (1.0 g) and 140 mg of lithium chloride were dissolved in 10 ml of N,N-dimethylformamide and the solution was refluxed for 48 hours. Then, 10 ml of water was added to the reaction liquid, and the mixture was extracted with 100 ml of ethyl acetate. The resulting extract was dried over sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (eluent: chloroform) to give 400 mg of diethyl 4-oxo-1,3-piperidinediacetate as an oily substance.

Provenance & Evidence