Ethanol → HCID 178472614, compound

Participants

Reaction Steps

Ethanol (38 ml), 0.90 g of Hydroxylamine hydrochloride, and 1.64 g of triethylamine were added to 3.0 g of ethyl 4-[4-(4-cyanophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetate, and the mixture was heated under reflux for 3 hours. The crystals formed were collected by filtration at the temperature of about 30° C, and recrystallized from chloroform-ethanol to give 2.27 g of ethyl 4-[4-(4-hydroxyamidinophenyl)-3-oxo-1-piperazinyl]-1-piperidineacetate

Provenance & Evidence