Hydrochloric Acid → HCID 178472612, compound

Participants

Reaction Steps

(±)-cis-Diethyl 4-[4-(4-hydroxyamidinophenyl)-1-piperazinyl]-1,3-piperidinediacetate (1.5 g) was dissolved in 50 ml of 1N hydrochloric acid and the solution was refluxed overnight. The reaction liquid was concentrated and the concentrate was purified by ODS column chromatography (eluent: water to water:methanol=1:1) to give 100 mg of (±)-cis-4-[4-(4-hydroxyamidinophenyl)-1-piperazinyl]-1-[(ethoxycarbonyl)methyl]piperidine-3-acetic acid trihydrochloride.

Provenance & Evidence