Sodium Hydroxide → HCID 18788790, compound

HRID 1106494Notes

Reaction equation

HRID 1106494 reaction equation
[O:1]([C:8]1[CH:17]=[CH:16][C:11]([C:12]([O:14]C)=[O:13])=[CH:10][C:9]=1[C:18]([F:21])([F:20])[F:19])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[O:1]([C:8]1[CH:17]=[CH:16][C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]=1[C:18]([F:19])([F:20])[F:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18788781HCID 18788781, compound

Product 1

HCID 18788790HCID 18788790, compoundYield 87.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

11 g of methyl 4-phenoxy-3-trifluoromethylbenzoate were dissolved in 200 ml of MeOH, 41 ml of a 1 N aqueous solution of NaOH were added and the mixture was stirred at RT for 24 h. The MeOH was then removed in vacuo, and the remaining mixture was diluted with 1 l of water and the whole adjusted to a pH of 2 with an aqueous solution of HCl; the precipitate was then filtered off. The latter was air-dried for 48 h, resulting in 9.2 g of an amorphous solid.

Workup

  1. customThe MeOH was then removed in vacuo
  2. additionthe remaining mixture was diluted with 1 l of water
  3. filtrationthe precipitate was then filtered off
  4. customThe latter was air-dried for 48 h

Sources & evidence

ORD record
ord-e2feada0c222482bbfb66dd89cf4008c
Source dataset
uspto-grants-2000_05
Patent number
US06057322

Reaction notes

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