Phenol → Methyl 2-methyl-5-nitro-4-phenylbenzoate

Participants

Reaction Steps

22.6 g of methyl 4-bromo-2-methyl-5-nitrobenzoate, 23 g of K2CO3 and 7.8 g of phenol were stirred at 120° C. for 2 hours in 300 ml of DMF. The solvent was removed in vacuo, 2 l of water were added, and the mixture was adjusted to pH=7 using aqueous HCl solution and extracted 3 times using 500 ml of EA each time. The organic phase was dried over Na2SO4, the solvent was removed in vacuo and chromatography on silica gel using EA/HEP 1:4 yielded 13 g of a colorless oil.

Provenance & Evidence