Cesium carbonate → Methyl 2-chloro-4-(4-(2-dimethylaminoethyl)phenoxy)-5-methylsulfonylbenzoate

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	Hordenine	HCID 68313	—
반응물	Sodium Bicarbonate	HCID 516892	—
반응물	Methyl 2-chloro-4-fluoro-5-methylsulfonylbenzoate	HCID 10611840	—
용매	N-methyl-2-pyrrolidone	HCID 13387	—
생성물	Methyl 2-chloro-4-(4-(2-dimethylaminoethyl)phenoxy)-5-methylsulfonylbenzoate	HCID 18788900	29.1%

반응 조건

온도	100 °C

반응 단계

534 mg of methyl 2-chloro-4-fluoro-5-methylsulfonylbenzoate, 331 mg of 4-(2-dimethylaminoethyl)phenol and 2.0 g of Cs2CO3 were dissolved in 10 ml of NMP and the mixture was stirred at 100° C. for 3 hours. The reaction mixture was poured onto 150 ml of a saturated aqueous NaHCO3 solution and extracted 3 times using 100 ml of EA each time. The organic phase was dried over Na2SO4 and the solvent was removed in vacuo. Chromatography on silica gel using EA/MeOH 3:1 yields 240 mg of a viscous oil.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US06057322
출처 데이터셋	uspto-grants-2000_05
ORD ID	ord-3918a93898e143f69244c804ea6d1915
출처 메모	uspto-grants-2000_05