Benzoic Acid → HCID 86755358, compound

Participants

Reaction Steps

A mixture of intermediate 1 (22.46 g), benzoic acid (11.8 g) and thiophene (4%, 2 ml) in methanol (440 ml) was hydrogenated with palladium-on-carbon (10%, 3 g) as a catalyst. After uptake of hydrogen (1 equivalent), the catalyst was filtered off. The filtrate was evaporated, yielding 30 g (99%) of (±)-ethyl cis-1,3,4,4a,5,9b-hexahydro-5-(phenylmethyl)-2H-pyrido[4,3-b]indole-2-carboxylate (intermediate 2).

Provenance & Evidence