Formamide → 6,7-Dimethoxy-3H-quinazolin-4-one

Participants

Reaction Conditions

Reaction Steps

A mixture of 4,5-dimethoxyanthranilic acid (1.97 g, 10 mmol) and formamide (1.0 ml, 25 mmol) was heated to 190° C. for 6 h under stirring. Water (5 ml) was added after cooling to approximately 80° C. and the mixture was stored at room temperature for about 3 h. The precipitate was filtered, washed with water and dried to give 6,7-dimethoxyquinazolin4-one in about 18% yield (0.370 g).

Provenance & Evidence