HCID 12464194, compound → HCID 18180253, compound

Participants

Reaction Steps

A mixture of 3-methoxyisoquinoline (800 mg, 5.03 mmol) and platinum dioxide (100 mg) in concentrated hydrochloric acid (10 ml) was shaken under an atmosphere of hydrogen at 40 psi for 5 h. The mixture was diluted with water, filtered through Celite™, basified with sodium hydroxide then extracted four times with ethyl acetate. The combined organic phases were dried (MgSO4) and concentrated to afford the title compound (600 mg) as a clear oil, MS (ES+) 164 (MH+). δH (CDCl3) 7.85 (1H, s), 6.43 (1H, s), 3.87 (3H, s), 2.65 (4H, m) and 1.75 (4H, m).

Provenance & Evidence