Ethanol → 5,5-Dimethyl-2-ethoxy-3-(3-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2,5-dihydrofuran

Participants

Role	Name	HCID	Charge
Reactant	Ethanol	HCID 702	—
Reactant	5,5-Dimethyl-3-(3-fluorophenyl)-2-hydroxy-4-(4-methylsulfonylphenyl)-2,5-dihydrofuran	HCID 9863787	—
Catalyst	Boron trifluoride etherate	HCID 8000	—
Product	5,5-Dimethyl-2-ethoxy-3-(3-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2,5-dihydrofuran	HCID 18788506	—

Reaction Steps

To a solution of 5,5-dimethyl-2-hydroxy-3-(3-fluorophenyl)-4-(4-(methylsulfonyl)phenyl)-2,5-dihydrofuran (Example 1, 500 mg, 1.38 mmol) in 5 mL of EtOH was added 3 drops of BF3.OEt2. The mixture was stirred at room temperature for 45 min, and the resulting precipitate was filtered and washed with EtOH to provide 497 mg of the title compound as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06057319
Source dataset	uspto-grants-2000_05
ORD ID	ord-367cf3486a0548fa83f6f20e3dadc5d6
Source note	uspto-grants-2000_05