Lithium Chloride → HCID 18789318, compound

Participants

Reaction Conditions

Reaction Steps

3-(5-Bromoindan-2-yl)carbonylamino-5-(4-methoxyphenyl)pyrazole (50 mg), tributylphenyltin (0.12 ml), a tris(dibenzylideneacetone)dipalladium chloroform complex (6 mg), tri-2-furylphosphine (11 mg) and lithium chloride (25 mg) were dissolved in N-methylpyrrolidone (1 ml) with heating, and the mixture was heated at 85° C. overnight. After allowing to cool, the reaction solution was concentrated under a reduced pressure. The residue was dissolved in ethyl acetate-hexane (1:1, 30 ml) and the solution was washed with saturated aqueous potassium fluoride solution and dried over anhydrous magnesium sulfate. The solvent was distilled away under a reduced pressure. The resultant residue was purified by preparative thin layer chromatography (chloroform: methanol=20:1) to obtain the title compound (4.4 mg).

Provenance & Evidence