Sulfuric Acid → HCID 70256118, compound

HRID 1106660Notes

Reaction equation

HRID 1106660 reaction equation
[C:1]([C:3]1([O:20][CH2:21][CH3:22])[CH:8]=[CH:7][C:6]([C:9]2(C(OC)=O)[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])=[CH:5][CH2:4]1)#[N:2].OS(O)(=O)=O>C(O)(=O)C>[C:1]([C:3]1([O:20][CH2:21][CH3:22])[CH:4]=[CH:5][C:6]([CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][C:10]2=[O:15])=[CH:7][CH2:8]1)#[N:2]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 70255269HCID 70255269, compound

Product 1

HCID 70256118HCID 70256118, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

4-Cyano-4-(2-ethoxy)phenyl-2-methoxycarbonylcyclohexanone (1.06 g, 3.5 mmol) was heated at reflux in acetic acid (24 mL) and 10% H2SO4 (13 mL) for 6 h. Extraction with benzene (3×10 mL), which was washed with K2CO3 solution, dried (Na2SO4), filtered and concentrated, gave a white solid (0.755 g, 88%): mp 116-121 C.

Workup

  1. extractionExtraction with benzene (3×10 mL), which
  2. washwas washed with K2CO3 solution
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-9e40c1f314c24447b86d223c95c135b4
Source dataset
uspto-grants-2000_05
Patent number
US06057350

Reaction notes

Loading…