Hydrogen chloride-ethyl acetate → HCID 86755372, compound

Participants

Reaction Steps

4N Hydrochloric acid/ethyl acetate solution (5.5 ml) was added to a solution of N-[3-(dimethylamino)propyl]-{2-[1-(N-octadecylcarbamoyl)-2-piperidyl]ethoxy}formamide (8.37 g) in ethyl acetate (252 ml) under argon gas atmosphere while being cooled with ice. The solution was stirred for 1.5 hours at room temperature. The deposited crystals were collected by filtration under a vacuum and was recrystallized with ethyl acetate, thereby yielding the entitled compound (8.12 g) as white crystal.

Provenance & Evidence