反应详情

To a suspension of 7.6 g of sodium hydride (60% dispersion in oil) in 200 mL of tetrahydrofuran under a nitrogen atmosphere was added dropwise at room temperature a solution consisting of 7.8 g of acetonitrile and 38.8 g of methyl 3-(trifluoromethyl)benzoate in 50 mL of tetrahydrofuran. Following addition, the suspension was stirred 1 h at ambient temperature, refluxed about 5 h, and then cooled to room temperature. Isopropyl alcohol (20 mL) was added dropwise at room temperature. After stirring about 15 min, the solvent was removed in vacuo, and about 200 mL of water was added to the residue. The aqueous suspension was washed with 3×50 mL diethyl ether and then acidified with concentrated hydrochloric acid to form a solid. The solid was isolated by filtration, washed 2×100 mL with water and then dissolved in methylene chloride. The organic solution was dried (MgSO4), filtered and concentrated to give 30.0 g of the title compound of Step A as a white solid melting at 51-55° C. 1H NMR (CDCl3): δ 8.1-8.2 (m,2H), 7.95 (d,1H), 7.7 (m,1H), 4.15 (s,2H); IR (mineral oil) 1704.1 cm-1.

1. additionwas added dropwise at room temperature a solution
2. additionaddition
3. temperaturerefluxed about 5 h
4. temperaturecooled to room temperature
5. stirringAfter stirring about 15 min
6. customthe solvent was removed in vacuo, and about 200 mL of water
7. additionwas added to the residue
8. washThe aqueous suspension was washed with 3×50 mL diethyl ether
9. customto form a solid
10. customThe solid was isolated by filtration
11. washwashed 2×100 mL with water
12. dissolutiondissolved in methylene chloride
13. dry with materialThe organic solution was dried (MgSO4)
14. filtrationfiltered
15. concentrationconcentrated