HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-Aminophenoxy)acetonitrile → N-[3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methanesulfonamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-Aminophenoxy)acetonitrile | HCID 18789699 | — |
| Reactant | HCID 18789725 | HCID 18789725 | — |
| Reactant | N-(3-chloro-5-cyanomethyl-2-methylphenyl) methanesulfonamide | HCID 53903521 | — |
| Product | N-[3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methanesulfonamide hydrochloride | HCID 18789717 | — |
Reaction Steps
N-(3-chloro-5-(4,5-dihydro-1H-imidazol-2-ylmethyl)-2-methylphenyl]methane-sulfonamide hydrochloride (mp 256.2-256.7° C.) was prepared from N-(3-chloro-5-cyanomethyl-2-methylphenyl) methanesulfonamide in a manner similar to that described in Example 1 for the preparation of N-[3-(4,5-dihydro-1H-imidazol-2-ylmethoxy)phenyl] methanesulfonamide hydrochloride from (3-aminophenoxy)acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06057349 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-ab984ee2dd6c40a0b4f4380f1f8ee4a2 |
| Source note | uspto-grants-2000_05 |