2-Methyl-3-nitroaniline → HCID 4433548, compound

HRID 1106760Notes

Reaction equation

HRID 1106760 reaction equation
[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[NH2:11].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[CH3:1][C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:11][S:13]([CH3:12])(=[O:15])=[O:14]

Participants

4

Reactant 2

HCID 117832-Methyl-3-nitroanilineHCID 31297Methanesulfonyl chloride

Product 1

HCID 4433548HCID 4433548, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 2-methyl-3-nitro-phenylamine (3 g) and methanesulfonyl chloride (1.6 mL) in pyridine (30 mL, from Mallinckrodt) was stirred at room temperature overnight. Pyridine was removed under reduced pressure. The residue was taken up with dichloromethane (Mallinckrodt) and washed with water and brine. After drying over sodium sulfate and evaporation of the solvent, N-(2-Methyl-3-nitro-phenyl)-methanesulfonamide (4 g) was obtained.

Workup

  1. customPyridine was removed under reduced pressure
  2. washwashed with water and brine
  3. dry with materialAfter drying over sodium sulfate and evaporation of the solvent

Sources & evidence

ORD record
ord-37e06238ca004d32b82fc8d68463c171
Source dataset
uspto-grants-2000_05
Patent number
US06057349

Reaction notes

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