反应详情

Allyl bromide (1.36 g, 11.25 mmol) was added to a mixture of N-(2-bromo-5-nitrophenyl)methanesulfonamide (1.66 g, 5.62 mmol) and cesium carbonate (5.49 g, 16.86 mmol) in methylethylketone (20 ml). The mixture was heated to reflux for 2 hr. The mixture was cooled and poured onto water. The product was extracted into ethyl acetate (2×75 ml) and the extracts were dried (anhydrous MgSO4) and concentrated to provide 1.88 g of N-allyl-N-(2-bromo-5-nitrophenyl)methanesulfonamide which required no purification.

1. temperatureThe mixture was heated
2. temperatureto reflux for 2 hr
3. temperatureThe mixture was cooled
4. additionpoured onto water
5. extractionThe product was extracted into ethyl acetate (2×75 ml)
6. dry with materialthe extracts were dried (anhydrous MgSO4)
7. concentrationconcentrated