反应详情

To a mixture of ethyl 4-[N-(2-benzyloxy-5-bromobenzyl)-aminomethyl]benzoate (1.4 g) in methanol (25 ml) was added 2N sodium hydroxide solution (7.7 ml). The mixture was heated at reflux for 30 minutes, left to stand for 2 hours at ambient temperature, the solvent evaporated and the residue mixed with water (20 ml). The mixture was acidified with acetic acid, the precipitate filtered off and crystallised form ethyl acetate to give the title compound (800 mg) mpt 209° C. The starting material was prepared as follows:

1. temperatureThe mixture was heated
2. temperatureat reflux for 30 minutes
3. waitleft
4. customthe solvent evaporated
5. additionthe residue mixed with water (20 ml)
6. filtrationthe precipitate filtered off
7. customcrystallised
8. customform ethyl acetate