反应详情

tert-Butyl 4-[N-(5-bromo-2-benzyloxybenzyl)-N-(4-carboxybenzyl)-amino]benzoate (example 3) (500 mg) was suspended in formic acid (2 ml) and heated on a steam bath until a clear solution was obtained. This solution was left at ambient temperature for 18 hours and the resulting solid filtered, washed with formic acid (2×1 ml) and dried under vacuum at 60° C. to give the title product (340 mg) m.p. 271° C.

1. temperatureheated on a steam bath until a clear solution
2. customwas obtained
3. filtrationthe resulting solid filtered
4. washwashed with formic acid (2×1 ml)
5. customdried under vacuum at 60° C.