Hydrochloric Acid → HCID 54158818, compound

Participants

Reaction Steps

To a solution of Example 10 (24.78 g, 85 mmol) in ethanol (200 mL) was added palladium catalyst (10% on carbon) (6.0 g) and HCl (4 M in dioxane) (4.5 mL, 18 mmol). This was hydrogenated at 30° C. for 6 hours and then filtered through Celite. The solvent was removed in vacuo, and column chromatography (ethyl acetate:methanol:ammonia 40:9:1) gave the product as a yellow oil, 82 mmol, 96%.

Provenance & Evidence