1,1'-Carbonyldiimidazole → HCID 70298427, compound

Participants

Reaction Steps

To a solution of 3-benzofuran acetic acid (1.446 g, 8.01 mmol) in THF (5 mL) at room temperature was added carbonyldiimidazole (1.31 g, 8.09 mmol). After stirring for 2 hours, a solution of Example 5 (2.68 g, 6.09 mmol) in THF (10 mL) was added. After stirring for 16 hours, all volatiles were removed in vacuo and the residue dissolved in ethyl acetate (300 mL). This solution was washed with saturated sodium hydrogencarbonate solution, then water, then saturated NaCl solution (50 mL of each). After drying (MgSO4) and concentration in vacuo, column chromatography (60:40 ethyl acetate:heptane) gave the desired product, 3.04 g, 83%.

Provenance & Evidence