Tetrabutylammonium Fluoride → HCID 70298568, compound

Participants

Reaction Steps

To a solution of Example 36 (0.90 g, 1.45 mmol) in tetrahydrofuran (10 mL) was added tetrabutylammonium fluoride (1.0 M in tetrahydrofuran) (1.45 mL, 1.45 mmol). The reaction was stirred at room temperature under argon for 2.5 hours, then half the solvent was removed in vacuo. After stirring for a further 30 minutes, the reaction was poured into water (15 mL) and brine (70 mL), and extracted with dichloromethane (3×70 mL). The organics were dried (MgSO4) and the solvent removed in vacuo. Column chromatography (ethyl acetate:methanol 4:1) gave the product as a clear oil, 1.32 mmol, 90%.

Provenance & Evidence