HCID 18788109, compound → HCID 18788154, compound

Participants

Reaction Steps

A suspension of 1-tert-butyloxycarbonylmethyl-4-benzyloxycarbonyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-1,4-benzodiazonine(1.52 g, 3.48 mmol), and 10% palladium on charcoal (0.2 g) in methanol (20 ml) was stirred under a hydrogen atmosphere for 4 hours. The reaction mixture was filtered through a pad of celite and the filtrate evaporated to give the crude product, which was purified by flash chromatography on silica gel with methanol-DCM(1:12) as eluant. (996 mg, 95%)

Provenance & Evidence