3,4-Dichlorophenyl isocyanate → HCID 18788135, compound

HRID 1106941Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[C:4]([N:9]=[C:10]=[O:11])[CH:5]=[CH:6][C:7]=1[Cl:8].[CH2:12]([N:19]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH:25]([CH2:32][CH3:33])[CH2:24][CH2:23][NH:22][CH2:21][C:20]1=[O:34])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1(C)C=CC=C(N=C=O)C=1.C(OC(CN1C2C=CC=CC=2CCCNCC1=O)=O)(C)(C)C>>[CH2:12]([N:19]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[CH:25]([CH2:32][CH3:33])[CH2:24][CH2:23][N:22]([C:10](=[O:11])[NH:9][C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)[CH2:21][C:20]1=[O:34])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

Participants

Reactant 4

HCID 76073,4-Dichlorophenyl isocyanate

HCID 69303m-Tolyl isocyanate

HCID 18788121HCID 18788121, compound

HCID 18788154HCID 18788154, compound

Product 1

HCID 18788135HCID 18788135, compound

Procedure

The compound was prepared by a similar method to that used in the preparation of example 49 except that 3,4-dichlorophenylisocyanate and 1-benzyl-7-ethyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-1,4-benzodiazonine were used in place of m-tolylisocyanate and 1-tert-butyloxycarbonylmethyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-1,4-benzodiazonine respectively in step j.

Workup

customThe compound was prepared by a similar method to

Sources & evidence

ORD record: ord-68c4fa4b8a1d4deab46603959a6d5bbe
Source dataset: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06057311

Reaction notes

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