HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxycarbonylglycine → HCID 131721789, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | H-Lys(Boc)-Pro-OtBu | HCID 14010669 | — |
| Solvent | dichloromethane N,N-dimethylformamide | HCID 22350042 | — |
| Product | HCID 131721789 | HCID 131721789 | 70.1% |
Reaction Steps
C] Z-Gly-OH (0.762 g, 3.64 mmoles) was dissolved in 15 ml of DMF/methylene chloride (1:1 v/v) and sequentially added with BOP (1.61 go 3.64 mmoles), HOBT (0.491 g, 3.64 mmoles), TEA (1.01 ml, 7.28 mmoles) and H-Lys(Boc)-Pro-OtBu (1.119 g, 2.8 mmoles) dissolved in 15 ml of the same mixture. The reaction mixture was treated as described under A]. There were obtained 1.16 g of Z-Gly-Lys(Boc)-Pro-OtBu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06057295 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-8deae65b5d2d4fd2ab18cb72b1f8d513 |
| Source note | uspto-grants-2000_05 |