HCID 15458324, compound → HCID 18790534, compound

HRID 1106980Notes

Reaction equation

HRID 1106980 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:33])[CH2:21][S:22][C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=[CH:25][CH:24]=3)=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.O1CCOCC1.[ClH:40]>>[ClH:40].[N:11]1([C:14]2[CH:19]=[CH:18][C:17]([C:20](=[O:33])[CH2:21][S:22][C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=[CH:25][CH:24]=3)=[CH:16][CH:15]=2)[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 15458324HCID 15458324, compound2×HCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18790534HCID 18790534, compoundYield 99%

Procedure

4-[2-[4-(4-tert-Butoxycarbonyl-1-piperazinyl)phenyl]-2-oxoethylthio]quinoline (Compound 49; 2.8 g, 6.0 mmol) was gradually added to an ice-cooled solution of 4N hydrochloride dioxane solution (40 ml). The reaction mixture was stirred at room temperature for one hour. The resulting precipitates were collected by filtration and washed well with dry dioxane and dry ether to obtain 2.8 g of the titled compound (99%).

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed well with dry dioxane and dry ether

Sources & evidence

ORD record
ord-b9c390d9eeab4427952e515fd64bef31
Source dataset
uspto-grants-2000_05
Patent number
US06057447

Reaction notes

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