Triethylamine → HCID 18790537, compound

Participants

Reaction Steps

4-[2-[4-(1-Piperazinyl)phenyl]-2-oxoethylthio]-quinoline hydrochloride (Compound 51; 2.20 g, 4.66 mmol) was suspended in dry acetone (300 ml). Triethylamine (6.60 ml, 47.2 mmol) was added at -15° C. to the suspension and, after 30 minutes, pivaloylchloride (1.25 ml, 10.0 mmol) was added dropwise to the suspension. The reaction mixture was stirred at room temperature overnight and the solvent was removed under reduced pressure. The residue was chromatographed by silica gel chromatography (dichloromethane:methanol=20:1) to obtain 1.50 g of the titled compound (72.0%).

Provenance & Evidence