Water → HCID 18790526, compound

Participants

Reaction Steps

4-[2-(4-Hydroxy-2-methoxyphenyl)-2-oxoethylthio]-quinoline (Compound 12; 83 mg, 0.25 mmol) and potassium carbonate(42 mg, 0.25 mmol) were suspended in dry DMF (2.0 ml). Hexylbromide (0.041 ml, 0.28 mmol) was addded at -15° C. to the suspension and stirred at room temperature overnight. The reaction mixture was added with water under ice cooling, extracted with ethyl acetate, washed with saturated saline solution and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure. The residue was chromatographed by silica gel chromatography (n-hexane:ethyl acetate=1:4) to obtain 82.1 mg of the titled compound (80.3%).

Provenance & Evidence