Ammonia → HCID 18790708, compound

HRID 1107027Notes

Reaction equation

HRID 1107027 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH:6]([N:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]([O:20]CC)=O)[C:7]2=[O:12])#[N:2].[NH3:23]>CO>[C:1]([C:3]1[CH:11]=[CH:10][CH:9]=[C:8]2[C:4]=1[CH2:5][CH:6]([N:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]([NH2:23])=[O:20])[C:7]2=[O:12])#[N:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18790686HCID 18790686, compound

Product 1

HCID 18790708HCID 18790708, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1-[(4-Cyano-1-oxoindan-2-yl)]imidazole-2-carboxamide can be obtained in the following way: a solution of 1.5 g of ethyl 1-[(4-cyano-1-oxoindan-2-yl)]imidazole-2-carboxylate in 130 ml of methanol is kept saturated for one hour at a temperature in the region of 20° C. with a stream of gaseous ammonia. The reaction mixture is then concentrated to dryness under reduced pressure (15 mm Hg; 2 kPa) at 50° C. 1.2 g of 1-[(4-cyano-1-oxoindan-2-yl)]imidazole-2-carboxamide are thus obtained, which product melts at 216° C.

Workup

  1. concentrationThe reaction mixture is then concentrated to dryness under reduced pressure (15 mm Hg; 2 kPa) at 50° C

Sources & evidence

ORD record
ord-329f86b08737487586e338f257471b4d
Source dataset
uspto-grants-2000_05
Patent number
US06057454

Reaction notes

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