N-(1,1-dimethyl-2-propynyl)benzamide → HCID 15411099, compound

Participants

Reaction Conditions

Reaction Steps

A round bottom flask was charged with N-(3-methylbutyn-3-yl)benzamide (5.0 g, 26.7 mmol), silver nitrate (9.1 mg, 0.2 mol %), and n-butyl acetate (20 mL). The resulting mixture was heated to 95° C. for 0.5 h, then cooled to room temperature. The reaction was washed with water, and the organic layer was dried over anhydrous sodium sulfate. The solvent was removed by evaporation under reduced pressure. The residue was dried in a vacuum oven to give 4,4-dimethyl-5-methylene-2-phenyloxazoline (4.67 g 93% yield) as a pale yellow oil (bp 70-75° C., 0.6 mm Hg).

Provenance & Evidence