HRID1107066

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID74840

Leucine, N-carboxy-, N-benzyl ester, L-

C14H19NO4

HCID2758030

dibenzo[b,d]furan-2-sulfonyl chloride

C12H7ClO3S

结构：N#Cc1c(Cl)cccc1Oc1ccc(S(=O)(=O)Cl)cc1

HCID2776917

4-(3-Chloro-2-Cyanophenoxy)Benzene-1-Sulfonyl Chloride

C13H7Cl2NO3S

HCID14484209

未命名化合物

PRODUCTS

生成物

结构：CC(C)CC[C@H](NC(=O)OCc1ccccc1)C(=O)C(N)C(=O)CNS(=O)(=O)c1ccc2oc3ccccc3c2c1

HCID86585348

未命名化合物

PROCEDURE

实验过程

Following the procedure of Example 51, except 2-dibenzofuransulfonyl chloride for 4-(3-Chloro-2-cyano-phenoxy)-phenyl sulfonyl chloride and Cbz-homo-leucine for Cbz-leucine, the title compound was prepared: MS(ES) M+Na+ =602.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5318b8c3ada940738096b6d8e2b25762
来源数据集: uspto-grants-2000_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06057362
来源说明: uspto-grants-2000_05

反应 SMILES

[CH:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[S:14](Cl)(=[O:16])=[O:15].ClC1C([C:36]#[N:37])=C(C=CC=1)OC1C=CC(S(Cl)(=O)=O)=CC=1.[C:38]([NH:48][C@H:49]([C:55]([OH:57])=O)[CH2:50][CH2:51][CH:52]([CH3:54])[CH3:53])([O:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:39].C([NH:68][C@H:69]([C:74]([OH:76])=O)CC(C)C)(OCC1C=CC=CC=1)=O>>[C:38]([NH:48][C@H:49]([C:55]([CH:69]([NH2:68])[C:74](=[O:76])[CH2:36][NH:37][S:14]([C:2]1[CH:3]=[CH:4][C:5]2[O:6][C:7]3[CH:13]=[CH:12][CH:11]=[CH:10][C:8]=3[C:9]=2[CH:1]=1)(=[O:16])=[O:15])=[O:57])[CH2:50][CH2:51][CH:52]([CH3:53])[CH3:54])([O:40][CH2:41][C:42]1[CH:43]=[CH:44][CH:45]=[CH:46][CH:47]=1)=[O:39]