Ethanol → HCID 18790065, compound

Participants

Reaction Steps

A solution of 0.463 g (0.91 mmol) of N-benzyloxy-3-(4-methoxyphenylsulfonyl)-3-ethyl-7-phenylheptanamide in 75 mL of EtOH is shaken for 3 days under 50 psi of H2 with 0.2 g of 10% Pd on carbon. The mixture is filtered and concentrated in vacuo. Purification by flash silica gel chromatography afforded 0.1 g (26%) of 3-(4-methoxybenzenesulfonyl)-3-ethyl-7-phenylheptanoic acid hydroxamide in the form of a white foam, m.p. 44-46° C.1H NMR (DMSO-d6) δ (TMS)0.97 (t, 3H), 1.45-1.9 (m, 8H), 2.4 (s, 2H), 2.55 (m, 2H), 3.87 (s, 3H), 7.1-7.25(m, 5H), 7.28 (d, 2H), 7.65 (d, 2H), 8.83 (s,1H), 10.6 (s,1H).

Provenance & Evidence