反应详情

A solution of sodium hydroxide (0.31 g, 7.7 mmol) in water (4 mL) is added to a solution of methyl 3-(3,4-dimethoxybenzenesulfonyl)-2,2-dimethyl-7-phenylheptanoate (0.78 g, 1.7 mmol) in MeOH (6 mL). The reaction is heated at reflux 24 hours. The solvent is then removed in vacuo, CH2Cl2 (20 mL) added and the solution washed with 1 N HCl (2×40 mL). The organic layer is dried over MgSO4 and the solvent removed in vacuo to afford 3-(3,4-dimethoxyphenylsulfonyl)-2,2-dimethyl-7-phenylheptanoic acid (0.54 g, 73%) 1H NMR (300 MHz, CDCl3) δ 7.47 (dd, J=8.5, 2.1 Hz, 1H), 7.36 (d, J=2.1 Hz, 1H), 7.26-7.16 (m, 3H), 7.02 (d, J=7.0 Hz, 2H), 6.90 (d, J=8.4 Hz, 1H), 3.93 (s, 3H), 3.92 (s, 3H), 3.76-3.73 (m, 1H), 2.46-2.41 (m, 2H), 2.06-2.00 (m, 1H), 1.65-1.60 (m, 2H), 1.48 (s, 3H), 1.45-1.35 (m, 3H), 1.29 (s, 3H); MS (FAB) m/e 434 (M+).

1. temperatureThe reaction is heated
2. temperatureat reflux 24 hours
3. customThe solvent is then removed in vacuo, CH2Cl2 (20 mL)
4. additionadded
5. washthe solution washed with 1 N HCl (2×40 mL)
6. dry with materialThe organic layer is dried over MgSO4
7. customthe solvent removed in vacuo