HCID 69906549, compound → HCID 76106777, compound

Participants

Reaction Steps

The titled compound is prepared according to the method used in the preparation of (±)-(2R*, R*)-3-(4-methoxybenzenesulfonyl)-7-phenyl-2-(2-phenoxyethyl)heptanoic acid hydroxyamide, except using (±)-(2R*, 3R*)-3-(4-methoxybenzenesulfonyl)-7-phenyl-2-(2-phenylsulfanyl-ethyl)heptanoic acid as the starting material. From (±)-(2R*, 3R*)-3-(4-methoxybenzenesulfonyl)-7-phenyl-2-(2-phenylsulfanylethyl)heptanoic acid (0.64 g, 1.2 mmol) provides (±)-(2R*, 3R*)-3-(4-methoxybenzenesulfonyl)-7-phenyl-2-(2-phenylsulfanylethyl)heptanoic acid hydroxyamide (0.5 g, 79%): 1H NMR (300 MHz, CDCl3) δ 9.44 (bs, 1H), 7.75 (d, J=8.9 Hz, 2H), 7.28-7.14 (m, 8H), 7.05 (d, J=7.2 Hz, 2H), 6.99 (d, J=9.0 Hz, 2H), 3.88 (s, 3H), 3.28-3.25 (m, 1H), 3.00-2.93 (m, 2H), 2.75-2.66 (m, 1H), 2.46 (t, J=7.3 Hz, 2H), 2.43-2.30 (m, 1H) 1.83-1.17 (m, 8H); MS (FAB) m/e 528 (M+H)+ ; Anal. (C28H33O5NS2.0.3 H2O) C, H, N.

Provenance & Evidence