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0 °C

To a solution of the title compound of Example 11, Step A (771 mg, 1-80 mmol) in dichloromethane (10 mL) was added dropwise diethylaminosulfur trifluoride (0.48 mL, 3.60 mmol) at 0° C. The reaction was stirred at 0° C. for 1 hour, quenched with cold water, and extracted with dichloromethane. The combined organic layers were washed with water, dried over magnesium sulfate, and concentrated under reduced pressure. The title compound of Step A, a compound of this invention, was isolated by flash chromatography (332 mg) as a foam melting at 60-64° C. 1H NMR (CDCl3) 87.7 (d, 1H), 7.4 (d, 1H), 7.1 (br s, 1H), 5.28 and 5.12 (two br s, 1 H), 4.6 (s, 2H), 1H), 4.2 (dd, 1H), 3.3 (ddd, 1H), 2.65 (m, 1H), 2.2 (m, 1H), 1.9-1.6 (m, 2H).

1. customquenched with cold water
2. extractionextracted with dichloromethane
3. washThe combined organic layers were washed with water
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated under reduced pressure