反应详情

A mixture of 11-bromomethyl-11H-dibenz[b,f][1,4]oxathiepine (6.15 g, 20 mmol, prepared similarly as described in Coll. Czech. Chem. Commun. 50, 1484, 1985), (R)-3-piperidinecarboxylic acid ethyl ester tartrate (4.7 g, 30 mmol) and chloroform (10 ml) was warmed to achieve dissolution. The solution was then allowed to stand for 1 week at room temperature, and was subsequently heated at reflux temperature for 7 h. After cooling, the mixture was diluted with benzene and washed with 5% ammonia. The organic phase was dried (potassium carbonate) and evaporated. The residue was purified by column chromatography on silica gel (55 g) using first benzene and then diethyl ether as eluents to give 4.1 g (53%) of (R)-1-(11H-dibenz[b,f][1,4]oxathiepin-11-ylmethyl)-3-piperidinecarboxylic acid ethyl ester as an oil.

1. customprepared similarly
2. dissolutiondissolution
3. waitto stand for 1 week at room temperature
4. temperaturewas subsequently heated
5. temperatureat reflux temperature for 7 h
6. temperatureAfter cooling
7. washwashed with 5% ammonia
8. dry with materialThe organic phase was dried (potassium carbonate)
9. customevaporated
10. customThe residue was purified by column chromatography on silica gel (55 g)