Acetic Anhydride → HCID 136029150, compound

HRID 1107324Notes

Reaction equation

HRID 1107324 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>>[C:23]([NH:1][C:2]1[N:7]=[C:6]2[N:8]=[C:9]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[O:19][CH2:20][CH2:21][CH3:22])[NH:10][C:11](=[O:12])[C:5]2=[CH:4][N:3]=1)(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 135670763HCID 135670763, compound

Product 1

HCID 136029150HCID 136029150, compound

Procedure

A stirred mixture of 7-amino-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.59 g) and acetic anhydride (5 ml) was heated under reflux for 1.5 hours. Excess acetic anhydride was removed under reduced pressure. The solid residue was washed with water and triturated with hot methanol to yield the title compound, 0.57 g, m.p. 273-4° C.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 1.5 hours
  3. customExcess acetic anhydride was removed under reduced pressure
  4. washThe solid residue was washed with water
  5. customtriturated with hot methanol

Sources & evidence

ORD record
ord-8371e7adb555468b9ec59d451951bec1
Source dataset
uspto-grants-2000_05
Patent number
US06060477

Reaction notes

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