HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 136000269, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Reactant | 7-Methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine | HCID 135670752 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 136000269 | HCID 136000269 | — |
Reaction Steps
In a similar manner to Example 57 reaction of 7-methylsulphonyl-4-oxo-2-(2-propoxyphenyl)-3,4-dihydropyrimido[4,5-d]pyrimidine (0.86 g), glycine ethyl ester hydrochloride (0.65 g) and triethylamine (0.47 g) in dichloromethane (15 ml) yielded the title compound, 0.38 g, m.p. 174.5-176° C. (recrystallized from ethanol:water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06060477 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-e41dbdc57c2a4c29be1c5b2fee85504b |
| Source note | uspto-grants-2000_05 |