Ammonia → HCID 135670753, compound

HRID 1107353Notes

Reaction equation

HRID 1107353 reaction equation
CS[C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1.[NH3:24]>>[NH2:24][C:3]1[N:4]=[N:5][C:6]2[C:12](=[O:13])[NH:11][C:10]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=3[O:20][CH2:21][CH2:22][CH3:23])=[N:9][C:7]=2[N:8]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 135670800HCID 135670800, compound

Product 1

HCID 135670753HCID 135670753, compound

Procedure

In a similar manner to that described in Example 87, 3-methylthio-8-oxo-6-(2-propoxyphenyl)-7,8-dihydropyrimido[4,5-e][1,2,4]triazine (1.42 g) was reacted with ethanolic ammonia (70 ml) for 20 hours to give the crude title compound, (0.80 g) which together with another sample (0.17 g), similarly prepared, was recrystallized from ethanol to afford the title compound, 0.54 g, m.p. 255-256° C.

Workup

  1. customto give the crude title compound, (0.80 g) which together with another sample (0.17 g)
  2. customsimilarly prepared
  3. customwas recrystallized from ethanol

Sources & evidence

ORD record
ord-e973ad5f346f4bd5a4b79732d6179e29
Source dataset
uspto-grants-2000_05
Patent number
US06060477

Reaction notes

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