Ammonia → 3-Amino-4-n-propylpridine-2-carboxamide

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 3-amino-4-n-propylpyridine-2-carboxylate (Preparation 5; 7.4 g, 0.035 mol) and liquid ammonia (60 ml) was heated in an autoclave at 100° C. for 18 hours. The mixture was allowed to cool and the ammonia to evaporate, then the residue was crystallized from methanol to give the title compound as a colourless solid (4.84 g, 76%), m.p. 139-141° C.

Provenance & Evidence