HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1107367Generated: October 27, 2026
Ammonia → 3-Amino-4-cyanopyridine-2-carboxamide
https://huagongshe.com/reaction/1107367
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Ethyl 3-amino-4-cyanopyridine-2-carboxylate | HCID 22462344 | — |
| Product | 3-Amino-4-cyanopyridine-2-carboxamide | HCID 22462404 | 94% |
Reaction Steps
A mixture of liquid ammonia (30 ml) and ethyl 3-amino-4-cyanopyridine-2-carboxylate (Preparation 11; 2.8 g, 0.0147 mol) was heated at 100° C. in an autoclave for 18 hours. The ammonia was allowed to evaporate and the resulting product crystallized from ethyl acetate to give the title compound as an off-white solid (2.2 g, 94%), m.p. >310° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06060477 |
|---|
| Source dataset | uspto-grants-2000_05 |
|---|
| ORD ID | ord-631924f17f874ffda6e1ce98a91584a4 |
|---|
| Source note | uspto-grants-2000_05 |
|---|
