HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylene Glycol → HCID 21968522, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | (10-Methoxy-6-methylergolin-8beta-yl)methanol | HCID 13536793 | — |
| Product | HCID 21968522 | HCID 21968522 | 75% |
Reaction Steps
A stirred solution of 10 g of 6-methyl-8β-hydroxymethyl-10α-methoxy-ergoline in 100 ml of ethylen glycol was treated with 7.5 ml of concentrated sulphuric acid at room temperature. After stirring for 3 hour, the solution was poured into ice water then made alkaline with concentrated sodium hydroxyde. The precipitated was collected washed with water, and crystallised from ehanol to provide the title compound in 75% yield, m.p. 201-205° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06060483 |
| Source dataset | uspto-grants-2000_05 |
| ORD ID | ord-79ae1dcbdf3f4944a9f6c7ee390e537b |
| Source note | uspto-grants-2000_05 |