m-Chloroperbenzoic acid → HCID 15450553, compound

Participants

Reaction Steps

To a dissolved solution of N-(1-benzyl-4-piperidinyl)-2-ethoxy-3-methyl-2-phenylbutanamide (invention compound, Compound No. 1) (400 mg, 1.01 mmole) in chloroform (20 ml) was added 70% m-chloroperbenzoic acid (271 mg, 1.1 mmole). The mixture was stirred at room temperature for 3 days. After the reaction was completed, the reaction mixture was washed with a saturated aqueous sodium bicarbonate solution. The organic layer was dried over anhydrous sodium sulfate. The solvent was then removed under reduced pressure. The residue was purified by a silica gel column to obtain the invention compound (Compound No. 16, 316 mg, 77.0%) were obtained as colorless solid.

Provenance & Evidence