1-Indanone → Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]indan-1-ol

HRID 1107422Notes

Reaction equation

HRID 1107422 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14]([C@H:17]4[CH2:25][C:24]5[C:19](=[CH:20][C:21](OC)=[CH:22][CH:23]=5)[C@H:18]4[OH:28])[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1.C1(=O)C2C(=CC=CC=2)CC1>>[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[C:10]([N:11]3[CH2:16][CH2:15][N:14]([C@H:17]4[CH2:25][C:24]5[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=5)[C@H:18]4[OH:28])[CH2:13][CH2:12]3)[C:5]=2[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 67351-IndanoneHCID 15860117Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]-6-methoxyindan-1-ol

Product 1

HCID 15860120Cis-2-[4-(2,3-dihydro[1,4]benzodioxin-5-yl)piperazin-1-yl]indan-1-ol

Procedure

Prepared in the same manner as the compound of Example 1, but using indan-1-one instead of 6-methoxyindan-1-one in Step 1.

Sources & evidence

ORD record
ord-8cf6854d679d4538bbc18244875d10ba
Source dataset
uspto-grants-2000_05
Patent number
US06060487

Reaction notes

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