5-Fluoro-1-indanone → HCID 10959998, compound

HRID 1107424Notes

Reaction equation

HRID 1107424 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[C:7](=[O:11])[CH2:6][CH2:5]2.[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3([OH:28])[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]3)[C:16]=2[O:15][CH2:14][CH2:13]1>>[O:12]1[C:17]2[CH:18]=[CH:19][CH:20]=[C:21]([C:22]3([OH:28])[CH2:23][CH2:24][N:25]([C@@H:6]4[CH2:5][C:4]5[C:8](=[CH:9][CH:10]=[C:2]([F:1])[CH:3]=5)[C@H:7]4[OH:11])[CH2:26][CH2:27]3)[C:16]=2[O:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 1365375-Fluoro-1-indanoneHCID 18787260HCID 18787260, compound

Product 1

HCID 10959998HCID 10959998, compound

Procedure

Prepared using, in succession, the methods described in Examples 1 and 2, but using 5-fluoroindan-1-one in Step 1 of Example 1, and using 4-(2,3-dihydro[1,4]benzodioxin-5-yl)-4-hydroxypiperidine in Step 2 of Example 1.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-aebb980d08e8448f9373b2b36fc641a7
Source dataset
uspto-grants-2000_05
Patent number
US06060487

Reaction notes

Loading…